Title |
MixSIH: a mixture model for single individual haplotyping
|
---|---|
Published in |
BMC Genomics, February 2013
|
DOI | 10.1186/1471-2164-14-s2-s5 |
Pubmed ID | |
Authors |
Hirotaka Matsumoto, Hisanori Kiryu |
Abstract |
Haplotype information is useful for various genetic analyses, including genome-wide association studies. Determining haplotypes experimentally is difficult and there are several computational approaches that infer haplotypes from genomic data. Among such approaches, single individual haplotyping or haplotype assembly, which infers two haplotypes of an individual from aligned sequence fragments, has been attracting considerable attention. To avoid incorrect results in downstream analyses, it is important not only to assemble haplotypes as long as possible but also to provide means to extract highly reliable haplotype regions. Although there are several efficient algorithms for solving haplotype assembly, there are no efficient method that allow for extracting the regions assembled with high confidence. |
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Mendeley readers
Geographical breakdown
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Researcher | 6 | 21% |
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Other | 1 | 4% |
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