Title |
Evaluation of prognostic markers for canine mast cell tumors treated with vinblastine and prednisone
|
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Published in |
BMC Veterinary Research, August 2008
|
DOI | 10.1186/1746-6148-4-32 |
Pubmed ID | |
Authors |
Joshua D Webster, Vilma Yuzbasiyan-Gurkan, Douglas H Thamm, Elizabeth Hamilton, Matti Kiupel |
Abstract |
Canine cutaneous mast cell tumor (MCT) is a common neoplastic disease associated with a variable biologic behavior. Surgery remains the primary treatment for canine MCT; however, radiation therapy (RT) and chemotherapy are commonly used to treat aggressive MCT. The goals of this study were to evaluate the prognostic utility of histologic grade, c-KIT mutations, KIT staining patterns, and the proliferation markers Ki67 and AgNORs in dogs postoperatively treated with vinblastine and prednisone +/- RT, and to compare the outcome of dogs treated with post-operative chemotherapy +/- RT to that of a prognostically matched group treated with surgery alone. Associations between prognostic markers and survival were evaluated. Disease-free intervals (DFI) and overall survival times (OS) of dogs with similar pretreatment prognostic indices postoperatively treated with chemotherapy were compared to dogs treated with surgery alone. |
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Geographical breakdown
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United States | 1 | 50% |
Unknown | 1 | 50% |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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United States | 3 | 2% |
Brazil | 3 | 2% |
Unknown | 143 | 96% |
Demographic breakdown
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Student > Master | 24 | 16% |
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Researcher | 18 | 12% |
Student > Postgraduate | 18 | 12% |
Student > Bachelor | 10 | 7% |
Other | 29 | 19% |
Unknown | 28 | 19% |
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Other | 6 | 4% |
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