Title |
Time course and progression of wild type α-Synuclein accumulation in a transgenic mouse model
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Published in |
BMC Neuroscience, January 2013
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DOI | 10.1186/1471-2202-14-6 |
Pubmed ID | |
Authors |
David Amschl, Jörg Neddens, Daniel Havas, Stefanie Flunkert, Roland Rabl, Heinrich Römer, Edward Rockenstein, Eliezer Masliah, Manfred Windisch, Birgit Hutter-Paier |
Abstract |
Progressive accumulation of α-synuclein (α-Syn) protein in different brain regions is a hallmark of synucleinopathic diseases, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. α-Syn transgenic mouse models have been developed to investigate the effects of α-Syn accumulation on behavioral deficits and neuropathology. However, the onset and progression of pathology in α-Syn transgenic mice have not been fully characterized. For this purpose we investigated the time course of behavioral deficits and neuropathology in PDGF-β human wild type α-Syn transgenic mice (D-Line) between 3 and 12 months of age. |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 81 | 98% |
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Researcher | 17 | 20% |
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Professor | 3 | 4% |
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Psychology | 3 | 4% |
Other | 5 | 6% |
Unknown | 17 | 20% |