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Neuropathology of supercentenarians - four autopsy case studies

Overview of attention for article published in Acta Neuropathologica Communications, September 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#47 of 1,032)
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
4 tweeters
facebook
2 Facebook pages
googleplus
1 Google+ user

Citations

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17 Dimensions

Readers on

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29 Mendeley
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Title
Neuropathology of supercentenarians - four autopsy case studies
Published in
Acta Neuropathologica Communications, September 2016
DOI 10.1186/s40478-016-0368-6
Pubmed ID
Authors

Masaki Takao, Nobuyoshi Hirose, Yasumichi Arai, Ban Mihara, Masaru Mimura

Abstract

Supercentenarians (aged 110 years old or more) are extremely rare in the world population (the number of living supercentenarians is estimated as 47 in the world), and details about their neuropathological information are limited. Based on previous studies, centenarians (aged 100-109 years old) exhibit several types of neuropathological changes, such as Alzheimer's disease and Lewy body disease pathology, primary age-related tauopathy, TDP-43 pathology, and hippocampal sclerosis. In the present study, we provide results from neuropathological analyses of four supercentenarian autopsy cases using conventional and immunohistochemical analysis for neurodegenerative disorders. In particular, we focused on the pathology of Alzheimer's disease and Lewy body disease, as well as the status of hippocampal sclerosis, TDP-43 pathology, aging-related tau astrogliopathy, and cerebrovascular diseases. Three cases were characterized as an "intermediate" level of Alzheimer's disease changes (NIA-AA guideline) and one was characterized as primary age-related tauopathy. TDP-43 deposits were present in the hippocampus in two cases. Neither Lewy body pathology nor hippocampal sclerosis was observed. Aging-related tau astrogliopathy was consistently observed, particularly in the basal forebrain. Small vessel diseases were also present, but they were relatively mild for cerebral amyloid-beta angiopathy and arteriolosclerosis. Although our study involved a small number of cases, the results provide a better understanding about human longevity. Neuropathological alterations associated with aging were mild to moderate in the supercentenarian brain, suggesting that these individuals might have some neuroprotective factors against aging. Future prospective studies and extensive molecular analyses are needed to determine the mechanisms of human longevity.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 17%
Student > Ph. D. Student 5 17%
Researcher 4 14%
Other 3 10%
Student > Postgraduate 3 10%
Other 5 17%
Unknown 4 14%
Readers by discipline Count As %
Neuroscience 9 31%
Medicine and Dentistry 7 24%
Agricultural and Biological Sciences 5 17%
Psychology 3 10%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 0 0%
Unknown 4 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2020.
All research outputs
#806,851
of 17,053,340 outputs
Outputs from Acta Neuropathologica Communications
#47
of 1,032 outputs
Outputs of similar age
#19,128
of 270,341 outputs
Outputs of similar age from Acta Neuropathologica Communications
#1
of 1 outputs
Altmetric has tracked 17,053,340 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,032 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,341 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them