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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Rare TREM2 variants associated with Alzheimer’s disease display reduced cell surface expression
|
|---|---|
| Published in |
Acta Neuropathologica Communications, September 2016
|
| DOI | 10.1186/s40478-016-0367-7 |
| Pubmed ID | |
| Authors |
Daniel W. Sirkis, Luke W. Bonham, Renan E. Aparicio, Ethan G. Geier, Eliana Marisa Ramos, Qing Wang, Anna Karydas, Zachary A. Miller, Bruce L. Miller, Giovanni Coppola, Jennifer S. Yokoyama |
| Abstract |
Rare variation in TREM2 has been associated with greater risk for Alzheimer's disease (AD). TREM2 encodes a cell surface receptor expressed on microglia and related cells, and the R47H variant associated with AD appears to affect the ability of TREM2 to bind extracellular ligands. In addition, other rare TREM2 mutations causing early-onset neurodegeneration are thought to impair cell surface expression. Using a sequence kernel association (SKAT) analysis in two independent AD cohorts, we found significant enrichment of rare TREM2 variants not previously characterized at the protein level. Heterologous expression of the identified variants showed that novel variants S31F and R47C displayed significantly reduced cell surface expression. In addition, we identified rare variant R136Q in a patient with language-predominant AD that also showed impaired surface expression. The results suggest rare TREM2 variants enriched in AD may be associated with altered TREM2 function and that AD risk may be conferred, in part, from altered TREM2 surface expression. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 38% |
| Switzerland | 2 | 25% |
| Greece | 1 | 13% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 85 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 19% |
| Researcher | 13 | 15% |
| Student > Master | 8 | 9% |
| Professor > Associate Professor | 6 | 7% |
| Student > Bachelor | 6 | 7% |
| Other | 17 | 20% |
| Unknown | 19 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 16 | 19% |
| Biochemistry, Genetics and Molecular Biology | 15 | 18% |
| Agricultural and Biological Sciences | 10 | 12% |
| Medicine and Dentistry | 7 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Other | 11 | 13% |
| Unknown | 22 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2018.
All research outputs
#2,382,685
of 22,886,568 outputs
Outputs from Acta Neuropathologica Communications
#402
of 1,383 outputs
Outputs of similar age
#43,623
of 337,011 outputs
Outputs of similar age from Acta Neuropathologica Communications
#5
of 30 outputs
Altmetric has tracked 22,886,568 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,383 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,011 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.