Title |
Functional relevance of dynamic properties of Dimeric NADP-dependent Isocitrate Dehydrogenases
|
---|---|
Published in |
BMC Bioinformatics, December 2012
|
DOI | 10.1186/1471-2105-13-s17-s2 |
Pubmed ID | |
Authors |
Rithvik Vinekar, Chandra Verma, Indira Ghosh |
Abstract |
Isocitrate Dehydrogenases (IDHs) are important enzymes present in all living cells. Three subfamilies of functionally dimeric IDHs (subfamilies I, II, III) are known. Subfamily I are well-studied bacterial IDHs, like that of Escherischia coli. Subfamily II has predominantly eukaryotic members, but it also has several bacterial members, many being pathogens or endosymbionts. subfamily III IDHs are NAD-dependent. The eukaryotic-like subfamily II IDH from pathogenic bacteria such as Mycobacterium tuberculosis IDH1 are expected to have regulation similar to that of bacteria which use the glyoxylate bypass to survive starvation. Yet they are structurally different from IDHs of subfamily I, such as the E. coli IDH. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 2 | 5% |
Portugal | 1 | 2% |
Belgium | 1 | 2% |
South Africa | 1 | 2% |
Unknown | 36 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 24% |
Student > Bachelor | 6 | 15% |
Researcher | 6 | 15% |
Student > Master | 5 | 12% |
Professor | 4 | 10% |
Other | 6 | 15% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 15 | 37% |
Agricultural and Biological Sciences | 12 | 29% |
Medicine and Dentistry | 3 | 7% |
Chemistry | 3 | 7% |
Decision Sciences | 1 | 2% |
Other | 3 | 7% |
Unknown | 4 | 10% |