Title |
Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed?
|
---|---|
Published in |
Malaria Journal, February 2007
|
DOI | 10.1186/1475-2875-6-16 |
Pubmed ID | |
Authors |
Andrew Vallely, Lisa Vallely, John Changalucha, Brian Greenwood, Daniel Chandramohan |
Abstract |
Falciparum malaria is an important cause of maternal, perinatal and neonatal morbidity in high transmission settings in Sub-Saharan Africa. Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP-IPT) has proven efficacious in reducing the burden of pregnancy-associated malaria but increasing levels of parasite resistance mean that the benefits of national SP-IPT programmes may soon be seriously undermined in much of the region. Hence, there is an urgent need to develop alternative drug regimens for IPT in pregnancy. This paper reviews published safety and efficacy data on various antimalarials and proposes several candidate combination regimens for assessment in phase II/III clinical trials. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 2% |
Tanzania, United Republic of | 2 | 1% |
Brazil | 1 | <1% |
Burkina Faso | 1 | <1% |
Thailand | 1 | <1% |
United States | 1 | <1% |
Unknown | 149 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 29 | 18% |
Student > Ph. D. Student | 25 | 16% |
Researcher | 21 | 13% |
Other | 12 | 8% |
Student > Bachelor | 11 | 7% |
Other | 33 | 21% |
Unknown | 27 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 54 | 34% |
Agricultural and Biological Sciences | 22 | 14% |
Nursing and Health Professions | 14 | 9% |
Social Sciences | 8 | 5% |
Biochemistry, Genetics and Molecular Biology | 7 | 4% |
Other | 23 | 15% |
Unknown | 30 | 19% |