Title |
Crosstalk between purinergic receptors and lipid mediators in leishmaniasis
|
---|---|
Published in |
Parasites & Vectors, September 2016
|
DOI | 10.1186/s13071-016-1781-1 |
Pubmed ID | |
Authors |
Mariana M. Chaves, Cláudio Canetti, Robson Coutinho-Silva |
Abstract |
Leishmaniasis is a neglected tropical disease affecting millions of people around the world caused by organisms of the genus Leishmania. Parasite escape mechanisms of the immune system confer the possibility of resistance and dissemination of the disease. A group of molecules that has become a target for Leishmania survival strategies are lipid mediators. Among them, leukotriene B4 (LTB4) has been described as a pro-inflammatory molecule capable of activating cells of the immune system to combat Leishmania. In an opposite way, prostaglandin E2 (PGE2) is a lipid mediator described as a deactivator of macrophages and neutrophils. The balance of these two molecules can be generated by extracellular nucleotides, such as adenosine 5'-triphosphate (ATP) and adenosine (Ado), which activate the purinergic receptors system. Herein, we discuss the role of extracellular nucleotides and the resulting balance of LTB4 and PGE2 in Leishmania fate, survival or death. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Italy | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 18% |
Student > Doctoral Student | 8 | 14% |
Student > Bachelor | 8 | 14% |
Student > Ph. D. Student | 6 | 11% |
Researcher | 5 | 9% |
Other | 9 | 16% |
Unknown | 11 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 11 | 19% |
Biochemistry, Genetics and Molecular Biology | 10 | 18% |
Agricultural and Biological Sciences | 7 | 12% |
Medicine and Dentistry | 5 | 9% |
Nursing and Health Professions | 2 | 4% |
Other | 8 | 14% |
Unknown | 14 | 25% |