Title |
A new web-based method for automated analysis of muscle histology
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Published in |
BMC Musculoskeletal Disorders, January 2013
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DOI | 10.1186/1471-2474-14-26 |
Pubmed ID | |
Authors |
Cordula Pertl, Markus Eblenkamp, Anja Pertl, Stefan Pfeifer, Erich Wintermantel, Hanns Lochmüller, Maggie C Walter, Sabine Krause, Christian Thirion |
Abstract |
Duchenne muscular dystrophy is an inherited degenerative neuromuscular disease characterised by rapidly progressive muscle weakness. Currently, curative treatment is not available. Approaches for new treatments that improve muscle strength and quality of life depend on preclinical testing in animal models. The mdx mouse model is the most frequently used animal model for preclinical studies in muscular dystrophy research. Standardised pathology-relevant parameters of dystrophic muscle in mdx mice for histological analysis have been developed in international, collaborative efforts, but automation has not been accessible to most research groups. A standardised and mainly automated quantitative assessment of histopathological parameters in the mdx mouse model is desirable to allow an objective comparison between laboratories. |
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France | 1 | 14% |
Unknown | 1 | 14% |
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Scientists | 2 | 29% |
Mendeley readers
Geographical breakdown
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Unknown | 76 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 22 | 28% |
Student > Ph. D. Student | 15 | 19% |
Student > Master | 7 | 9% |
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Professor | 4 | 5% |
Other | 11 | 14% |
Unknown | 13 | 17% |
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Veterinary Science and Veterinary Medicine | 2 | 3% |
Other | 5 | 6% |
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