Title |
Integrative pathway dissection of molecular mechanisms of moxLDL-induced vascular smooth muscle phenotype transformation
|
---|---|
Published in |
BMC Cardiovascular Disorders, January 2013
|
DOI | 10.1186/1471-2261-13-4 |
Pubmed ID | |
Authors |
George S Karagiannis, Jochen Weile, Gary D Bader, Joe Minta |
Abstract |
Atherosclerosis (AT) is a chronic inflammatory disease characterized by the accumulation of inflammatory cells, lipoproteins and fibrous tissue in the walls of arteries. AT is the primary cause of heart attacks and stroke and is the leading cause of death in Western countries. To date, the pathogenesis of AT is not well-defined. Studies have shown that the dedifferentiation of contractile and quiescent vascular smooth muscle cells (SMC) to the proliferative, migratory and synthetic phenotype in the intima is pivotal for the onset and progression of AT. To further delineate the mechanisms underlying the pathogenesis of AT, we analyzed the early molecular pathways and networks involved in the SMC phenotype transformation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 67% |
Scientists | 2 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 3 | 4% |
United States | 1 | 1% |
Germany | 1 | 1% |
Canada | 1 | 1% |
Unknown | 70 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 22% |
Student > Ph. D. Student | 11 | 14% |
Student > Master | 9 | 12% |
Other | 7 | 9% |
Student > Bachelor | 6 | 8% |
Other | 13 | 17% |
Unknown | 13 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 26% |
Biochemistry, Genetics and Molecular Biology | 16 | 21% |
Medicine and Dentistry | 13 | 17% |
Computer Science | 2 | 3% |
Engineering | 2 | 3% |
Other | 9 | 12% |
Unknown | 14 | 18% |