Title |
Proliferation zones in the axolotl brain and regeneration of the telencephalon
|
---|---|
Published in |
Neural Development, January 2013
|
DOI | 10.1186/1749-8104-8-1 |
Pubmed ID | |
Authors |
Malcolm Maden, Laurie A Manwell, Brandi K Ormerod |
Abstract |
Although the brains of lower vertebrates are known to exhibit somewhat limited regeneration after incisional or stab wounds, the Urodele brain exhibits extensive regeneration after massive tissue removal. Discovering whether and how neural progenitor cells that reside in the ventricular zones of Urodeles proliferate to mediate tissue repair in response to injury may produce novel leads for regenerative strategies. Here we show that endogenous neural progenitor cells resident to the ventricular zone of Urodeles spontaneously proliferate, producing progeny that migrate throughout the telencephalon before terminally differentiating into neurons. These progenitor cells appear to be responsible for telencephalon regeneration after tissue removal and their activity may be up-regulated by injury through an olfactory cue. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 2 | 9% |
Poland | 2 | 9% |
United States | 2 | 9% |
Paraguay | 1 | 4% |
Bosnia and Herzegovina | 1 | 4% |
France | 1 | 4% |
Malaysia | 1 | 4% |
Germany | 1 | 4% |
United Kingdom | 1 | 4% |
Other | 0 | 0% |
Unknown | 11 | 48% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 14 | 61% |
Scientists | 5 | 22% |
Practitioners (doctors, other healthcare professionals) | 3 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Hungary | 1 | <1% |
Germany | 1 | <1% |
Brazil | 1 | <1% |
Sweden | 1 | <1% |
Argentina | 1 | <1% |
United States | 1 | <1% |
Unknown | 141 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 33 | 22% |
Student > Bachelor | 23 | 16% |
Researcher | 21 | 14% |
Student > Master | 14 | 10% |
Student > Doctoral Student | 5 | 3% |
Other | 14 | 10% |
Unknown | 37 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 35 | 24% |
Biochemistry, Genetics and Molecular Biology | 29 | 20% |
Neuroscience | 21 | 14% |
Medicine and Dentistry | 7 | 5% |
Psychology | 3 | 2% |
Other | 9 | 6% |
Unknown | 43 | 29% |