Title |
Use of "biokitHSV-2 Rapid Assay" to improve the positive predictive value of Focus HerpeSelect HSV-2 ELISA
|
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Published in |
BMC Infectious Diseases, October 2005
|
DOI | 10.1186/1471-2334-5-84 |
Pubmed ID | |
Authors |
Rhoda Ashley Morrow, David Friedrich, Amalia Meier, Lawrence Corey |
Abstract |
Commercially available assays to detect antibodies to the herpes simplex virus type 2 (HSV-2)-specific glycoprotein gG-2 have markedly improved serologic diagnosis of HSV-2 infection. However, even tests with high specificity can have low positive predictive values in low prevalence populations. HSV-2 is a chronic, life-long viral infection that requires both medical attention and potential alterations in health care strategy. As such, the concern for false positive diagnoses is high confirmatory testing is routine for other viral serologies such as HIV and hepatitis C. We evaluated such a strategy for HSV-2 serology by using an easily performed commercial test, biokitHSV-2 rapid test ("Biokit"; Biokit USA, Lexington MA) as a confirmatory test for the widely used gG-2 specific serology ("Focus;" HerpeSelect HSV-2 ELISA; Focus Diagnostics, Cypress CA). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 4% |
Unknown | 23 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 21% |
Other | 4 | 17% |
Student > Master | 3 | 13% |
Student > Ph. D. Student | 2 | 8% |
Student > Doctoral Student | 2 | 8% |
Other | 3 | 13% |
Unknown | 5 | 21% |
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Agricultural and Biological Sciences | 2 | 8% |
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Environmental Science | 1 | 4% |
Other | 3 | 13% |
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