Title |
Human leukocyte antigen-G expression in differentiated human airway epithelial cells: lack of modulation by Th2-associated cytokines
|
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Published in |
Respiratory Research, January 2013
|
DOI | 10.1186/1465-9921-14-4 |
Pubmed ID | |
Authors |
Steven R White, Dagan A Loisel, Randi Stern, Bharathi Laxman, Timothy Floreth, Bertha A Marroquin |
Abstract |
Human leukocyte antigen (HLA)-G is a nonclassical class I antigen with immunomodulatory roles including up-regulation of suppressor T regulatory lymphocytes. HLA-G was recently identified as an asthma susceptibility gene, and expression of a soluble isoform, HLA-G5, has been demonstrated in human airway epithelium. Increased presence of HLA-G5 has been demonstrated in bronchoalveolar lavage fluid recovered from patients with mild asthma; this suggests a role for this isoform in modulating airway inflammation though the mechanisms by which this occurs is unclear. Airway inflammation associated with Th2 cytokines such as IL-4 and IL-13 is a principal feature of asthma, but whether these cytokines elicit expression of HLA-G is not known. |
X Demographics
Geographical breakdown
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Argentina | 1 | 20% |
Germany | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 39% |
Unspecified | 3 | 17% |
Researcher | 3 | 17% |
Student > Doctoral Student | 1 | 6% |
Student > Master | 1 | 6% |
Other | 1 | 6% |
Unknown | 2 | 11% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 4 | 22% |
Unspecified | 3 | 17% |
Immunology and Microbiology | 2 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 1 | 6% |
Unknown | 3 | 17% |