Title |
Adjuvant radiotherapy and chemotherapy in breast cancer: 30 year follow-up of survival
|
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Published in |
BMC Cancer, July 2010
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DOI | 10.1186/1471-2407-10-398 |
Pubmed ID | |
Authors |
Colin S McArdle, Donald C McMillan, Nicola Greenlaw, David S Morrison |
Abstract |
The long term outcome (more than 15 years) of adjuvant treatment in patients with primary operable breast cancer has rarely been examined. A randomised clinical trial of radiotherapy, chemotherapy (28 day cycles of cyclophosphamide, methotrexate and 5-fluorouracil) or both on women with primary operable breast cancer (n = 322) was followed-up for a median of 27 years. 260 (81%) patients died, 204 (78%) from breast cancer. Cancer specific survival (SE) at 10 years, 20 years and 30 years was 41 (3)%, 34 (3)% and 33 (3)% respectively. Presence of more than 3 involved lymph nodes increased cancer-specific mortality (HR 1.88, 95% CI 1.34-2.63) after adjustment for age, socio-economic deprivation and adjuvant treatment. Both age (HR 1.63, 95% CI 1.19-2.22) and involved lymph nodes (HR 1.59, 95% CI 1.17-2.14) were significant predictors of all-cause mortality after adjustment for other factors. There was no significant difference in all-cause or cancer-specific survival between patients in each of the 3 treatment arms. The present study highlights the long term impact of node positive disease but does not indicate that any regimen was associated with significantly better long-term survival. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 16% |
Student > Master | 3 | 12% |
Student > Bachelor | 3 | 12% |
Professor | 2 | 8% |
Student > Doctoral Student | 2 | 8% |
Other | 7 | 28% |
Unknown | 4 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 36% |
Agricultural and Biological Sciences | 3 | 12% |
Nursing and Health Professions | 1 | 4% |
Business, Management and Accounting | 1 | 4% |
Psychology | 1 | 4% |
Other | 3 | 12% |
Unknown | 7 | 28% |