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Default in plasma and intestinal IgA responses during acute infection by simian immunodeficiency virus

Overview of attention for article published in Retrovirology, May 2012
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26 Mendeley
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Title
Default in plasma and intestinal IgA responses during acute infection by simian immunodeficiency virus
Published in
Retrovirology, May 2012
DOI 10.1186/1742-4690-9-43
Pubmed ID
Authors

Nada Chaoul, Chantal Burelout, Sandrine Peruchon, Beatrice Nguyen van Buu, Pascale Laurent, Alexis Proust, Martine Raphael, Olivier Garraud, Roger Le Grand, Sophie Prevot, Yolande Richard

Abstract

Conflicting results regarding changes in mucosal IgA production or in the proportions of IgA plasma cells in the small and large intestines during HIV-infection have been previously reported. Except in individuals repeatedly exposed to HIV-1 but yet remaining uninfected, HIV-specific IgAs are frequently absent in mucosal secretions from HIV-infected patients. However, little is known about the organization and functionality of mucosal B-cell follicles in acute HIV/SIV infection during which a T-dependent IgA response should have been initiated. In the present study, we evaluated changes in B-cell and T-cell subsets as well as the extent of apoptosis and class-specific plasma cells in Peyer's Patches, isolated lymphoid follicles, and lamina propria. Plasma levels of IgA, BAFF and APRIL were also determined.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Italy 1 4%
Unknown 24 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 31%
Student > Ph. D. Student 4 15%
Student > Master 3 12%
Professor 2 8%
Other 1 4%
Other 3 12%
Unknown 5 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 42%
Medicine and Dentistry 5 19%
Immunology and Microbiology 3 12%
Biochemistry, Genetics and Molecular Biology 2 8%
Nursing and Health Professions 1 4%
Other 0 0%
Unknown 4 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2013.
All research outputs
#15,261,106
of 22,693,205 outputs
Outputs from Retrovirology
#776
of 1,103 outputs
Outputs of similar age
#104,694
of 164,812 outputs
Outputs of similar age from Retrovirology
#32
of 78 outputs
Altmetric has tracked 22,693,205 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,103 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,812 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.