Title |
Default in plasma and intestinal IgA responses during acute infection by simian immunodeficiency virus
|
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Published in |
Retrovirology, May 2012
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DOI | 10.1186/1742-4690-9-43 |
Pubmed ID | |
Authors |
Nada Chaoul, Chantal Burelout, Sandrine Peruchon, Beatrice Nguyen van Buu, Pascale Laurent, Alexis Proust, Martine Raphael, Olivier Garraud, Roger Le Grand, Sophie Prevot, Yolande Richard |
Abstract |
Conflicting results regarding changes in mucosal IgA production or in the proportions of IgA plasma cells in the small and large intestines during HIV-infection have been previously reported. Except in individuals repeatedly exposed to HIV-1 but yet remaining uninfected, HIV-specific IgAs are frequently absent in mucosal secretions from HIV-infected patients. However, little is known about the organization and functionality of mucosal B-cell follicles in acute HIV/SIV infection during which a T-dependent IgA response should have been initiated. In the present study, we evaluated changes in B-cell and T-cell subsets as well as the extent of apoptosis and class-specific plasma cells in Peyer's Patches, isolated lymphoid follicles, and lamina propria. Plasma levels of IgA, BAFF and APRIL were also determined. |
Mendeley readers
Geographical breakdown
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Unknown | 24 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 15% |
Student > Master | 3 | 12% |
Professor | 2 | 8% |
Other | 1 | 4% |
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Nursing and Health Professions | 1 | 4% |
Other | 0 | 0% |
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