Title |
Glycerol: An unexpected major metabolite of energy metabolism by the human malaria parasite
|
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Published in |
Malaria Journal, March 2009
|
DOI | 10.1186/1475-2875-8-38 |
Pubmed ID | |
Authors |
Lu-Yun Lian, Mohammed Al-Helal, Abd Majid Roslaini, Nicholas Fisher, Patrick G Bray, Stephen A Ward, Giancarlo A Biagini |
Abstract |
Malaria is a global health emergency, and yet our understanding of the energy metabolism of the principle causative agent of this devastating disease, Plasmodium falciparum, remains rather basic. Glucose was shown to be an essential nutritional requirement nearly 100 years ago and since this original observation, much of the current knowledge of Plasmodium energy metabolism is based on early biochemical work, performed using basic analytical techniques (e.g. paper chromatography), carried out almost exclusively on avian and rodent malaria. Data derived from malaria parasite genome and transcriptome studies suggest that the energy metabolism of the parasite may be more complex than hitherto anticipated. This study was undertaken in order to further characterize the fate of glucose catabolism in the human malaria parasite, P. falciparum. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 4% |
Germany | 3 | 3% |
India | 1 | 1% |
Switzerland | 1 | 1% |
Czechia | 1 | 1% |
United States | 1 | 1% |
Unknown | 78 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 27 | 30% |
Student > Master | 17 | 19% |
Researcher | 14 | 16% |
Other | 5 | 6% |
Student > Bachelor | 4 | 4% |
Other | 15 | 17% |
Unknown | 7 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 41 | 46% |
Biochemistry, Genetics and Molecular Biology | 12 | 13% |
Chemistry | 5 | 6% |
Medicine and Dentistry | 5 | 6% |
Immunology and Microbiology | 4 | 4% |
Other | 10 | 11% |
Unknown | 12 | 13% |