Title |
Measurement of Plasmodium falciparum transmission intensity using serological cohort data from Indonesian schoolchildren
|
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Published in |
Malaria Journal, January 2013
|
DOI | 10.1186/1475-2875-12-21 |
Pubmed ID | |
Authors |
Michael T Bretscher, Supargiyono Supargiyono, Mahardika A Wijayanti, Dian Nugraheni, Anis N Widyastuti, Neil F Lobo, William A Hawley, Jackie Cook, Chris J Drakeley |
Abstract |
As malaria transmission intensity approaches zero, measuring it becomes progressively more difficult and inefficient because parasite-positive individuals are hard to detect. This situation may arise shortly before achieving local elimination, or during surveillance post-elimination to prevent reintroduction. Antibody responses against the parasite last longer than the infections themselves. This "footprint" of infection may thus be used for assessing transmission intensity. A statistical approach is presented for measuring the seroconversion rate (SCR), a correlate of the force of infection, from individual-level longitudinal data on antibody titres in an area of low Plasmodium falciparum transmission. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
Malaysia | 1 | 1% |
Ghana | 1 | 1% |
Unknown | 80 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 18 | 21% |
Researcher | 17 | 20% |
Student > Ph. D. Student | 12 | 14% |
Student > Doctoral Student | 7 | 8% |
Other | 5 | 6% |
Other | 10 | 12% |
Unknown | 15 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 22 | 26% |
Medicine and Dentistry | 18 | 21% |
Immunology and Microbiology | 5 | 6% |
Nursing and Health Professions | 4 | 5% |
Engineering | 3 | 4% |
Other | 14 | 17% |
Unknown | 18 | 21% |