Title |
In vitro activity of tigecycline in combination with various antimicrobials against multidrug resistant Acinetobacter baumannii
|
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Published in |
Annals of Clinical Microbiology and Antimicrobials, May 2009
|
DOI | 10.1186/1476-0711-8-18 |
Pubmed ID | |
Authors |
Luigi Principe, Silvia D'Arezzo, Alessandro Capone, Nicola Petrosillo, Paolo Visca |
Abstract |
Infections sustained by multidrug-resistant (MDR) and pan-resistant Acinetobacter baumannii have become a challenging problem in Intensive Care Units. Tigecycline provided new hope for the treatment of MDR A. baumannii infections, but isolates showing reduced susceptibility have emerged in many countries, further limiting the therapeutic options. Empirical combination therapy has become a common practice to treat patients infected with MDR A. baumannii, in spite of the limited microbiological and clinical evidence supporting its efficacy. Here, the in vitro interaction of tigecycline with seven commonly used anti-Acinetobacter drugs has been assessed. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 1 | 1% |
Ecuador | 1 | 1% |
Kenya | 1 | 1% |
South Africa | 1 | 1% |
Canada | 1 | 1% |
Unknown | 84 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 16% |
Student > Ph. D. Student | 12 | 13% |
Student > Master | 11 | 12% |
Student > Postgraduate | 10 | 11% |
Other | 10 | 11% |
Other | 18 | 20% |
Unknown | 14 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 29% |
Agricultural and Biological Sciences | 16 | 18% |
Biochemistry, Genetics and Molecular Biology | 8 | 9% |
Immunology and Microbiology | 6 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
Other | 13 | 15% |
Unknown | 15 | 17% |