Title |
SignaLink 2 – a signaling pathway resource with multi-layered regulatory networks
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Published in |
BMC Systems Biology, January 2013
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DOI | 10.1186/1752-0509-7-7 |
Pubmed ID | |
Authors |
Dávid Fazekas, Mihály Koltai, Dénes Türei, Dezső Módos, Máté Pálfy, Zoltán Dúl, Lilian Zsákai, Máté Szalay-Bekő, Katalin Lenti, Illés J Farkas, Tibor Vellai, Péter Csermely, Tamás Korcsmáros |
Abstract |
Signaling networks in eukaryotes are made up of upstream and downstream subnetworks. The upstream subnetwork contains the intertwined network of signaling pathways, while the downstream regulatory part contains transcription factors and their binding sites on the DNA as well as microRNAs and their mRNA targets. Currently, most signaling and regulatory databases contain only a subsection of this network, making comprehensive analyses highly time-consuming and dependent on specific data handling expertise. The need for detailed mapping of signaling systems is also supported by the fact that several drug development failures were caused by undiscovered cross-talk or regulatory effects of drug targets. We previously created a uniformly curated signaling pathway resource, SignaLink, to facilitate the analysis of pathway cross-talks. Here, we present SignaLink 2, which significantly extends the coverage and applications of its predecessor. |
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Peru | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
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Mendeley readers
Geographical breakdown
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United Kingdom | 2 | 1% |
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Portugal | 1 | <1% |
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Spain | 1 | <1% |
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Readers by professional status | Count | As % |
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Student > Master | 25 | 15% |
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Student > Doctoral Student | 11 | 6% |
Other | 26 | 15% |
Unknown | 23 | 13% |
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Biochemistry, Genetics and Molecular Biology | 33 | 19% |
Computer Science | 15 | 9% |
Medicine and Dentistry | 12 | 7% |
Chemistry | 6 | 4% |
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Unknown | 30 | 18% |