Fatal Mycobacterium colombiense/cytomegalovirus coinfection associated with acquired immunodeficiency due to autoantibodies against interferon gamma: a case report

https://t.co/WDjdf6dyMI "and finally, susceptible P. aeruginosa ventilator-associated pneumonia with septic shock and MOF leading to death."

https://t.co/WDjdf6dyMI "The clinical course was complicated by the presence of multiresistant P. aeruginosa infection post-EBUS mediastinitis, CMV pneumonitis with dissemination,"

https://t.co/WDjdf6dyMI "Therefore, the final diagnosis was immunodeficiency secondary to the production of autoantibodies against IFN-γ, which resulted in post-obstructive pneumonia caused by lymphadenitis and disseminated infection of M. colombiense."

https://t.co/WDjdf6dyMI "The IFN-γ titer—defined as the dilution of a patient’s plasma that inhibits 50% fixation of 125 pg/mL IFN-γ in a standard IFN-γ ELISA assay (eBioscience ELISA kit)—was positive at 1:53725."