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Salivary psoriasin (S100A7) correlates with diffusion capacity of carbon monoxide in a large cohort of systemic sclerosis patients

Overview of attention for article published in Journal of Translational Medicine, September 2016
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Title
Salivary psoriasin (S100A7) correlates with diffusion capacity of carbon monoxide in a large cohort of systemic sclerosis patients
Published in
Journal of Translational Medicine, September 2016
DOI 10.1186/s12967-016-1023-5
Pubmed ID
Authors

Laura Giusti, Francesca Sernissi, Elena Donadio, Federica Ciregia, Camillo Giacomelli, Gino Giannaccini, Maria Rosa Mazzoni, Antonio Lucacchini, Laura Bazzichi

Abstract

Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and the internal organs. In a previous work we suggested a correlation between levels of salivary psoriasin (S100A7) and pulmonary involvement in SSc patients. The goals of this study are to determine the distribution characteristics of psoriasin in whole saliva (WS) of SSc and healthy donor populations and define its predictive value on diffusion capacity of carbon monoxide (DLCO), along with others clinical parameters. Salivary level of psoriasin was determined by ELISA kit in 134 SSc patients, 63 Raynaud syndrome patients, 40 patients affected by other connective diseases (non-case) and 74 healthy control subjects. A significant increase of salivary psoriasin was observed in SSc patients when compared with other healthy and pathological controls. Moreover, we confirmed the efficacy of salivary psoriasin to correlate with DLCO in a large cohort of SSc patients. Overall our results suggest a rapid, non invasive and low costing method which can help clinicians in the evaluation of SSc pulmonary involvement.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 17%
Other 3 13%
Student > Postgraduate 2 8%
Student > Master 2 8%
Student > Doctoral Student 1 4%
Other 4 17%
Unknown 8 33%
Readers by discipline Count As %
Medicine and Dentistry 8 33%
Biochemistry, Genetics and Molecular Biology 5 21%
Agricultural and Biological Sciences 3 13%
Nursing and Health Professions 1 4%
Unknown 7 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2016.
All research outputs
#15,383,207
of 22,886,568 outputs
Outputs from Journal of Translational Medicine
#2,238
of 4,004 outputs
Outputs of similar age
#211,711
of 332,538 outputs
Outputs of similar age from Journal of Translational Medicine
#50
of 80 outputs
Altmetric has tracked 22,886,568 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
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