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Transthoracic delivery of large devices into the left ventricle through the right ventricle and interventricular septum: preclinical feasibility

Overview of attention for article published in Critical Reviews in Diagnostic Imaging, January 2013
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Title
Transthoracic delivery of large devices into the left ventricle through the right ventricle and interventricular septum: preclinical feasibility
Published in
Critical Reviews in Diagnostic Imaging, January 2013
DOI 10.1186/1532-429x-15-10
Pubmed ID
Authors

Majdi Halabi, Kanishka Ratnayaka, Anthony Z Faranesh, Michael S Hansen, Israel M Barbash, Michael A Eckhaus, Joel R Wilson, Marcus Y Chen, Michael C Slack, Ozgur Kocaturk, William H Schenke, Victor J Wright, Robert J Lederman

Abstract

ABSTRACT: BACKGROUND: We aim to deliver large appliances into the left ventricle through the right ventricle and across the interventricular septum. This transthoracic access route exploits immediate recoil of the septum, and lower transmyocardial pressure gradient across the right versus left ventricular free wall. The route may enhance safety and allow subxiphoid rather than intercostal traversal. METHODS: The entire procedure was performed under real-time CMR guidance. An "active" CMR needle crossed the chest, right ventricular free wall, and then the interventricular septum to deliver a guidewire then used to deliver an 18Fr introducer. Afterwards, the right ventricular free wall was closed with a nitinol occluder. Immediate closure and late healing of the unrepaired septum and free wall were assessed by oximetry, angiography, CMR, and necropsy up to four weeks afterwards. RESULTS: The procedure was successful in 9 of 11 pigs. One failed because of refractory ventricular fibrillation upon needle entry, and the other because of inadequate guidewire support. In all ten attempts, the right ventricular free wall was closed without hemopericardium. There was neither immediate nor late shunt on oximetry, X-ray angiography, or CMR. The interventricular septal tract fibrosed completely.Transventricular trajectories planned on human CT scans suggest comparable intracavitary working space and less acute entry angles than a conventional atrial transseptal approach. CONCLUSION: Large closed-chest access ports can be introduced across the right ventricular free wall and interventricular septum into the left ventricle. The septum recoils immediately and heals completely without repair. A nitinol occluder immediately seals the right ventricular wall. The entry angle is more favorable to introduce, for example, prosthetic mitral valves than a conventional atrial transseptal approach.

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Geographical breakdown

Country Count As %
United States 2 7%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Other 5 17%
Student > Master 4 13%
Professor > Associate Professor 4 13%
Student > Ph. D. Student 2 7%
Student > Bachelor 2 7%
Other 3 10%
Unknown 10 33%
Readers by discipline Count As %
Medicine and Dentistry 9 30%
Engineering 8 27%
Agricultural and Biological Sciences 1 3%
Computer Science 1 3%
Business, Management and Accounting 1 3%
Other 0 0%
Unknown 10 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2013.
All research outputs
#23,084,818
of 25,728,855 outputs
Outputs from Critical Reviews in Diagnostic Imaging
#1,293
of 1,386 outputs
Outputs of similar age
#263,664
of 294,872 outputs
Outputs of similar age from Critical Reviews in Diagnostic Imaging
#29
of 39 outputs
Altmetric has tracked 25,728,855 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,386 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.