Title |
Alcohol use and depression: link with adherence and viral suppression in adult patients on antiretroviral therapy in rural Lesotho, Southern Africa: a cross-sectional study
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Published in |
BMC Public Health, September 2016
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DOI | 10.1186/s12889-016-3209-4 |
Pubmed ID | |
Authors |
Bernard Cerutti, Barbara Broers, Motlomelo Masetsibi, Olatunbosun Faturiyele, Likabelo Toti-Mokoteli, Mokete Motlatsi, Joelle Bader, Thomas Klimkait, Niklaus D Labhardt |
Abstract |
Depression and alcohol use disorder have been shown to be associated with poor adherence to antiretroviral therapy (ART). Studies examining their association with viral suppression in rural Africa are, however, scarce. This study reports prevalence of depressive symptoms and alcohol use disorder, and their potential association with adherence and viral suppression in adult patients on ART in ten clinics in rural Lesotho, Southern Africa. Among 1,388 adult patients (69 % women), 80.7 % were alcohol abstinent, 6.3 % were hazardous drinkers (men: 10.7 %, women: 4.4 %, p < 0.001). The prevalence of depressive symptoms was 28.8 % (men 20.2 %, women 32.7 %, p < 0.001). Both alcohol consumption (adjusted odds-ratio: 2.09, 95 % CI: 1.58-2.77) and alcohol use disorder (2.73, 95 % CI: 1.68-4.42) were significantly associated with poor adherence. There was, however, no significant association with viral suppression. Whereas the results of this study confirm previously reported association of alcohol use disorder with adherence to ART, there was no association with viral suppression. April 28th 2014; NCT02126696 . |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 14% |
Switzerland | 1 | 14% |
Unknown | 5 | 71% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 71% |
Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 104 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 21 | 20% |
Student > Ph. D. Student | 15 | 14% |
Researcher | 14 | 13% |
Student > Bachelor | 6 | 6% |
Student > Doctoral Student | 6 | 6% |
Other | 18 | 17% |
Unknown | 24 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 21 | 20% |
Nursing and Health Professions | 20 | 19% |
Psychology | 7 | 7% |
Social Sciences | 7 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
Other | 16 | 15% |
Unknown | 28 | 27% |