Title |
Targeting the Wnt/β-catenin pathway in endometriosis: a potentially effective approach for treatment and prevention
|
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Published in |
Molecular and Cellular Therapies, November 2014
|
DOI | 10.1186/s40591-014-0036-9 |
Pubmed ID | |
Authors |
Sachiko Matsuzaki, Revaz Botchorishvili, Jean Luc Pouly, Michel Canis |
Abstract |
Endometriosis is a chronic, estrogen-dependent disease associated with infertility and pelvic pain. Endometriosis is defined by the presence of extra-uterine endometrial tissue. It affects approximately 10% of reproductive-aged women. However, the underlying etiology, pathogenesis and pathophysiology remain to be fully elucidated. Knowledge of these factors is indispensable for the development of targeted therapies for prevention and treatment of endometriosis. Several studies, including those from our laboratory, have suggested that aberrant activation of the Wnt/β-catenin pathway may be involved in the pathophysiology of endometriosis. This is a review of the literature focused on the aberrant activation of the Wnt/β-catenin pathway in patients with endometriosis, and on how targeting the Wnt/targeting pathway may be a potentially effective approach for treating and/or preventing endometriosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | 2% |
Austria | 1 | 2% |
Unknown | 41 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 14% |
Student > Bachelor | 6 | 14% |
Student > Master | 5 | 12% |
Student > Doctoral Student | 3 | 7% |
Researcher | 3 | 7% |
Other | 8 | 19% |
Unknown | 12 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 30% |
Biochemistry, Genetics and Molecular Biology | 9 | 21% |
Agricultural and Biological Sciences | 6 | 14% |
Computer Science | 1 | 2% |
Nursing and Health Professions | 1 | 2% |
Other | 0 | 0% |
Unknown | 13 | 30% |