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Plasma cytokines IL-6, IL-8, and IL-10 are associated with the development of acute respiratory distress syndrome in patients with severe traumatic brain injury

Overview of attention for article published in Critical Care, September 2016
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  • Good Attention Score compared to outputs of the same age (66th percentile)

Mentioned by

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8 X users

Citations

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82 Dimensions

Readers on

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119 Mendeley
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Title
Plasma cytokines IL-6, IL-8, and IL-10 are associated with the development of acute respiratory distress syndrome in patients with severe traumatic brain injury
Published in
Critical Care, September 2016
DOI 10.1186/s13054-016-1470-7
Pubmed ID
Authors

Imo P. Aisiku, Jose-Miguel Yamal, Pratik Doshi, Julia S. Benoit, Shankar Gopinath, Jerry C. Goodman, Claudia S. Robertson

Abstract

Patients with severe traumatic brain injury (TBI) are at risk of the development of acute respiratory distress syndrome (ARDS). TBI and ARDS pathophysiologic mechanisms are known to independently involve significant inflammatory responses. The literature on the association between plasma inflammatory cytokines and ARDS in patients with TBI is sparse. The study was a secondary analysis of the safety of a randomized trial of erythropoietin and transfusion threshold in patients with severe TBI. Inflammatory markers within the first 24 hours after injury were compared in patients who developed ARDS and patients without ARDS, using Cox proportional hazards models. There were 200 patients enrolled in the study. The majority of plasma and cerebrospinal fluid (CSF) cytokine levels were obtained within 6 hours. Plasma proinflammatory markers IL-6 and IL-8 and anti-inflammatory marker IL-10 were associated with the development of ARDS (adjusted hazard ratio (HR) = 1.55, confidence interval (CI) = 1.14, 2.11, P = 0.005 for IL-6; adjusted HR = 1.32, CI = 1.10, 1.59, P = 0.003 for IL-8). Plasma markers of IL-6, IL-8, and IL-10 are associated with ARDS in patients with severe TBI. NCT00313716 registered 4/2006.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
Unknown 118 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 13%
Student > Master 14 12%
Student > Doctoral Student 13 11%
Researcher 11 9%
Student > Ph. D. Student 10 8%
Other 26 22%
Unknown 29 24%
Readers by discipline Count As %
Medicine and Dentistry 40 34%
Biochemistry, Genetics and Molecular Biology 10 8%
Agricultural and Biological Sciences 5 4%
Psychology 5 4%
Pharmacology, Toxicology and Pharmaceutical Science 5 4%
Other 19 16%
Unknown 35 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2020.
All research outputs
#7,778,071
of 25,373,627 outputs
Outputs from Critical Care
#4,172
of 6,554 outputs
Outputs of similar age
#108,022
of 329,606 outputs
Outputs of similar age from Critical Care
#103
of 125 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,606 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.