Title |
Adenocarcinoma of Mullerian origin: review of pathogenesis, molecular biology, and emerging treatment paradigms
|
---|---|
Published in |
Gynecologic Oncology Research and Practice, May 2015
|
DOI | 10.1186/s40661-015-0008-z |
Pubmed ID | |
Authors |
Lauren Patterson Cobb, Stephanie Gaillard, Yihong Wang, Ie-Ming Shih, Angeles Alvarez Secord |
Abstract |
Traditionally, epithelial ovarian, tubal, and peritoneal cancers have been viewed as separate entities with disparate origins, pathogenesis, clinical features, and outcomes. Additionally, previous classification systems for ovarian cancer have proposed two primary histologic groups that encompass the standard histologic subtypes. Recent data suggest that these groupings no longer accurately reflect our knowledge surrounding these cancers. In this review, we propose that epithelial ovarian, tubal, and peritoneal carcinomas represent a spectrum of disease that originates in the Mullerian compartment. We will discuss the incidence, classification, origin, molecular determinants, and pathologic analysis of these cancers that support the conclusion they should be collectively referred to as adenocarcinomas of Mullerian origin. As our understanding of the molecular and pathologic profiling of adenocarcinomas of Mullerian origin advances, we anticipate treatment paradigms will shift towards genomic driven therapeutic interventions. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Taiwan | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 7 | 16% |
Other | 5 | 11% |
Student > Ph. D. Student | 4 | 9% |
Researcher | 4 | 9% |
Student > Master | 4 | 9% |
Other | 8 | 18% |
Unknown | 12 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 14 | 32% |
Biochemistry, Genetics and Molecular Biology | 8 | 18% |
Agricultural and Biological Sciences | 2 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Environmental Science | 1 | 2% |
Other | 4 | 9% |
Unknown | 14 | 32% |