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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Epigenetic modulators as therapeutic targets in prostate cancer
|
|---|---|
| Published in |
Clinical Epigenetics, September 2016
|
| DOI | 10.1186/s13148-016-0264-8 |
| Pubmed ID | |
| Authors |
Inês Graça, Eva Pereira-Silva, Rui Henrique, Graham Packham, Simon J. Crabb, Carmen Jerónimo |
| Abstract |
Prostate cancer is one of the most common non-cutaneous malignancies among men worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or histone modifications, are key drivers of prostate carcinogenesis. These epigenetic defects might be due to deregulated function and/or expression of the epigenetic machinery, affecting the expression of several important genes. Remarkably, epigenetic modifications are reversible and numerous compounds that target the epigenetic enzymes and regulatory proteins were reported to be effective in cancer growth control. In fact, some of these drugs are already being tested in clinical trials. This review discusses the most important epigenetic alterations in prostate cancer, highlighting the role of epigenetic modulating compounds in pre-clinical and clinical trials as potential therapeutic agents for prostate cancer management. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 25% |
| United Kingdom | 2 | 25% |
| Colombia | 1 | 13% |
| France | 1 | 13% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 13% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 173 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 31 | 18% |
| Student > Ph. D. Student | 26 | 15% |
| Researcher | 22 | 13% |
| Student > Bachelor | 22 | 13% |
| Student > Master | 12 | 7% |
| Other | 23 | 13% |
| Unknown | 37 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 68 | 39% |
| Agricultural and Biological Sciences | 22 | 13% |
| Medicine and Dentistry | 16 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
| Nursing and Health Professions | 4 | 2% |
| Other | 13 | 8% |
| Unknown | 44 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2024.
All research outputs
#2,370,817
of 25,312,451 outputs
Outputs from Clinical Epigenetics
#148
of 1,431 outputs
Outputs of similar age
#38,634
of 329,034 outputs
Outputs of similar age from Clinical Epigenetics
#5
of 21 outputs
Altmetric has tracked 25,312,451 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,431 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,034 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.