Title |
Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression
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Published in |
Respiratory Research, September 2010
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DOI | 10.1186/1465-9921-11-131 |
Pubmed ID | |
Authors |
Shyamala Ganesan, Andrea N Faris, Adam T Comstock, Sangbrita S Chattoraj, Asamanja Chattoraj, John R Burgess, Jeffrey L Curtis, Fernando J Martinez, Suzanna Zick, Marc B Hershenson, Uma S Sajjan |
Abstract |
Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis, emphysema and irreversible airflow limitation. These changes are thought to be due to oxidative stress and an imbalance of proteases and antiproteases. Quercetin, a plant flavonoid, is a potent antioxidant and anti-inflammatory agent. We hypothesized that quercetin reduces lung inflammation and improves lung function in elastase/lipopolysaccharide (LPS)-exposed mice which show typical features of COPD, including airways inflammation, goblet cell metaplasia, and emphysema. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Australia | 1 | <1% |
Unknown | 103 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 16% |
Student > Doctoral Student | 10 | 9% |
Researcher | 9 | 8% |
Student > Bachelor | 8 | 8% |
Other | 6 | 6% |
Other | 27 | 25% |
Unknown | 29 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 24% |
Medicine and Dentistry | 19 | 18% |
Biochemistry, Genetics and Molecular Biology | 11 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
Immunology and Microbiology | 4 | 4% |
Other | 11 | 10% |
Unknown | 30 | 28% |