Title |
Passive transfer of collagen XVII-specific antibodies induces sustained blistering disease in adult mice
|
---|---|
Published in |
Orphanet Journal of Rare Diseases, January 2013
|
DOI | 10.1186/1750-1172-8-17 |
Pubmed ID | |
Authors |
Mircea Teodor Chiriac, Emilia Licarete, Alexandra Gabriela Sas, Andreea Maria Rados, Iulia Lupan, Anca Mirela Chiriac, Hilda Speth, Vlad Pop-Vancia, Iacob Domsa, Alina Sesarman, Octavian Popescu, Cassian Sitaru |
Abstract |
Bullous pemphigoid is a subepidermal blistering disorder associated with tissue-bound and circulating autoantibodies directed mainly to the hemidesmosomal component collagen XVII. While recapitulating the main immunopathological features of the human disease, frank skin blistering does not develop in the absence of skin rubbing in experimental pemphigoid models that have been established in neonatal mice. Moreover, due to their experimental design they only allow for short-term disease observation. In the present study we aimed to establish a model that reproduces the frank skin blistering seen in patients and allows for longer observation times. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 5% |
Unknown | 20 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 38% |
Researcher | 3 | 14% |
Student > Postgraduate | 2 | 10% |
Professor | 1 | 5% |
Professor > Associate Professor | 1 | 5% |
Other | 1 | 5% |
Unknown | 5 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 29% |
Agricultural and Biological Sciences | 3 | 14% |
Immunology and Microbiology | 3 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Chemistry | 1 | 5% |
Other | 0 | 0% |
Unknown | 6 | 29% |