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Evaluation of intravenous regional perfusion with amphotericin B and dimethylsulfoxide to treat horses for pythiosis of a limb

Overview of attention for article published in BMC Veterinary Research, July 2015
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Title
Evaluation of intravenous regional perfusion with amphotericin B and dimethylsulfoxide to treat horses for pythiosis of a limb
Published in
BMC Veterinary Research, July 2015
DOI 10.1186/s12917-015-0472-z
Pubmed ID
Authors

Renata GS Dória, Mariana B Carvalho, Silvio H Freitas, Luciane M Laskoski, Edson M Colodel, Fábio S Mendonça, Marco AG Silva, Renan Grigoletto, Paulo Fantinato Neto

Abstract

Treatment for horses with pythiosis of a limb is challenging. This study aims to evaluate the effects of administering amphotericin B in a 10 % solution of dimethylsulfoxide by intravenous regional limb perfusion (IRLP) to treat horses for cutaneous pythiosis of a limb. All 15 of the horses treated had complete resolutions of their lesion between 6 to 9 weeks after a single IRLP treatment. No complications were observed at the site of venipuncture for IRLP. Before initiation of treatment, there was anemia and marked leucocytosis which resolved following treatment. Serum biochemistry showed no significant changes. IRLP administration of amphotericin B in a 10 % DMSO solution was easily performed, relatively inexpensive and an effective treatment for treating horses for pythiosis of a limb and resolved the infection with no complications.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Other 6 24%
Student > Bachelor 3 12%
Student > Master 3 12%
Student > Doctoral Student 2 8%
Researcher 2 8%
Other 2 8%
Unknown 7 28%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 10 40%
Agricultural and Biological Sciences 4 16%
Medicine and Dentistry 2 8%
Biochemistry, Genetics and Molecular Biology 1 4%
Unknown 8 32%