Title |
BATS: a Bayesian user-friendly software for Analyzing Time Series microarray experiments
|
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Published in |
BMC Bioinformatics, October 2008
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DOI | 10.1186/1471-2105-9-415 |
Pubmed ID | |
Authors |
Claudia Angelini, Luisa Cutillo, Daniela De Canditiis, Margherita Mutarelli, Marianna Pensky |
Abstract |
Gene expression levels in a given cell can be influenced by different factors, namely pharmacological or medical treatments. The response to a given stimulus is usually different for different genes and may depend on time. One of the goals of modern molecular biology is the high-throughput identification of genes associated with a particular treatment or a biological process of interest. From methodological and computational point of view, analyzing high-dimensional time course microarray data requires very specific set of tools which are usually not included in standard software packages. Recently, the authors of this paper developed a fully Bayesian approach which allows one to identify differentially expressed genes in a 'one-sample' time-course microarray experiment, to rank them and to estimate their expression profiles. The method is based on explicit expressions for calculations and, hence, very computationally efficient. |
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Geographical breakdown
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Demographic breakdown
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Researcher | 23 | 35% |
Student > Ph. D. Student | 16 | 24% |
Professor | 5 | 8% |
Student > Master | 5 | 8% |
Student > Postgraduate | 4 | 6% |
Other | 10 | 15% |
Unknown | 3 | 5% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Mathematics | 3 | 5% |
Other | 6 | 9% |
Unknown | 8 | 12% |