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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Efficient generation and reversion of chromosomal translocations using CRISPR/Cas technology
|
|---|---|
| Published in |
BMC Genomics, September 2016
|
| DOI | 10.1186/s12864-016-3084-5 |
| Pubmed ID | |
| Authors |
Sergey Lekomtsev, Sofia Aligianni, Ana Lapao, Tilmann Bürckstümmer |
| Abstract |
Chromosomal translocations are a hallmark of cancer cells and give rise to fusion oncogenes. To gain insight into the mechanisms governing tumorigenesis, adequate model cell lines are required. We employ the versatile CRISPR/Cas system to engineer cell lines in which chromosomal translocations are either generated de novo (CD74-ROS1) or existing translocations are reverted back to the original configuration (BCR-ABL1). To this end, we co-apply two guide RNAs to artificially generate two breakpoints and screen for spontaneous fusion events by PCR. The approach we use is efficient and delivers clones bearing translocationsin a predictable fashion. Detailed analysis suggests that the clones display no additional undesired alterations, implying that the approach is robust and precise. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 14% |
| Spain | 1 | 14% |
| Unknown | 5 | 71% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 43% |
| Scientists | 3 | 43% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Italy | 1 | 1% |
| Unknown | 70 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 22% |
| Student > Bachelor | 14 | 19% |
| Researcher | 13 | 18% |
| Student > Master | 6 | 8% |
| Other | 5 | 7% |
| Other | 7 | 10% |
| Unknown | 11 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 26 | 36% |
| Agricultural and Biological Sciences | 21 | 29% |
| Medicine and Dentistry | 6 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Computer Science | 2 | 3% |
| Other | 2 | 3% |
| Unknown | 13 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2016.
All research outputs
#2,486,643
of 23,881,329 outputs
Outputs from BMC Genomics
#752
of 10,793 outputs
Outputs of similar age
#42,993
of 323,676 outputs
Outputs of similar age from BMC Genomics
#14
of 313 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,793 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,676 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 313 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.