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X Demographics
Mendeley readers
Attention Score in Context
| Title |
SEPT9 and SHOX2 DNA methylation status and its utility in the diagnosis of colonic adenomas and colorectal adenocarcinomas
|
|---|---|
| Published in |
Clinical Epigenetics, September 2016
|
| DOI | 10.1186/s13148-016-0267-5 |
| Pubmed ID | |
| Authors |
Alexander Semaan, Anne van Ellen, Sebastian Meller, Dominik Bergheim, Vittorio Branchi, Philipp Lingohr, Diane Goltz, Jörg C. Kalff, Glen Kristiansen, Hanno Matthaei, Dimitrios Pantelis, Dimo Dietrich |
| Abstract |
Colorectal cancer (CRC) appear to arise from precursor lesions in a well-characterized adenoma-carcinoma sequence. Significant efforts have been invested to develop biomarkers that identify early adenocarcinomas and adenomas with high-grade dysplasia, since these are believed to harbor a particularly high risk for malignant transition and thus require resection. Promoter methylation of SEPT9 and SHOX2 has been suggested as a biomarker for various solid malignant tumors. Hence, the present study aimed to test their biomarker potential in CRC and precursor lesions. Assessment of promoter methylation of SEPT9 distinguished adenomas and CRC from controls as well as advanced from non-advanced adenomas (all p < 0.001). Correspondingly, SHOX2 methylation levels in adenomas and colorectal carcinomas were significantly higher compared to those in normal control tissues (p < 0.001). Histologic transition from adenomas to CRC was paralleled by amplification of the SEPT9 gene locus. SEPT9/SHOX2 methylation assays may help to distinguish colorectal cancer and adenomas from normal and inflammatory colonic tissue, as well as advanced from non-advanced adenomas. Further studies need to validate these findings before introduction in clinical routine. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 45 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 18% |
| Student > Ph. D. Student | 7 | 16% |
| Researcher | 6 | 13% |
| Professor > Associate Professor | 3 | 7% |
| Student > Doctoral Student | 2 | 4% |
| Other | 6 | 13% |
| Unknown | 13 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 14 | 31% |
| Medicine and Dentistry | 11 | 24% |
| Agricultural and Biological Sciences | 4 | 9% |
| Unspecified | 1 | 2% |
| Chemistry | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 13 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2016.
All research outputs
#13,479,192
of 22,889,074 outputs
Outputs from Clinical Epigenetics
#673
of 1,260 outputs
Outputs of similar age
#169,030
of 320,233 outputs
Outputs of similar age from Clinical Epigenetics
#18
of 21 outputs
Altmetric has tracked 22,889,074 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,260 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,233 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.