@hectorsalas @NeuroscienceNew @wetbee_ @BalzaClarita @BelzaClarita @xai @elonmusk WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines https://t.co/wvg0tJ7VTy
2014: WNT4 is unique ER target in #lobular https://t.co/04RgMxyD5D '16: Key in models of ILC anti-estrogen resistance https://t.co/sd9L5zvb3e '19: Acts w/o canonical secretion and is intracellular https://t.co/EiWldmdfMF '20: Regs mTOR/S6K/mitochondria htt
We identified WNT4 as a critical driver of #lobular breast cancer cell growth and survival (https://t.co/WVNhYu35Fp), and naturally wanted to target that to kill cancer cells. We weren't sure how to target WNT4 though, since it was yet unclear how WNT4 sig
The long-term estrogen-deprived (LTED) models of MDA MB 134VI and SUM44PE, mimicking AI rx conditions, were originally reported in 2016, but we focused on WNT4 (I'm biased 😀). https://t.co/sd9L5zvb3e Tian took the analysis to the full transcriptome!