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Mendeley readers
Attention Score in Context
| Title |
Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply
|
|---|---|
| Published in |
Journal of Translational Medicine, September 2016
|
| DOI | 10.1186/s12967-016-1033-3 |
| Pubmed ID | |
| Authors |
Linfeng Xu, Xuefeng Qiu, Yanting Zhang, Kai Cao, Xiaozhi Zhao, Jinhui Wu, Yiqiao Hu, Hongqian Guo |
| Abstract |
To investigate the effect of perfluorochemical preparations in enhancing radiotherapy, perfluocarbon nanoparticles were by encapsulating perfluorohexane into liposome [lip(PFH)]. After intravenous injection, lip(PFH) could accumulate in the tumor site over time, with a prominent accumulation in tumor 24 h post injection. X-ray was delivered to the tumor site 24 h after the injection of lip(PFH) under room air. The experimental mice were randomized into four groups: control (saline), lip(PFH) (lip(PFH) only), X-ray (X-ray only), and lip(PFH) + X-ray (lip(PFH) with X-ray radiation). Tumor volume and histology were monitored to assess treatment efficacy. Tumor growth was significantly reduced in mice received lip(PFH) and X-ray compared with X-ray only. The histological data also revealed more destruction of tumor tissue in lip(PFH) + X-ray group compared with X-ray only. In addition, lip(PFH) did not show any significant tissue damage to major organs or induce significant liver/kidney dysfunction. Lip(PFH) could accumulate in the tumor site and enhance radiotherapy without additional oxygen supply. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Qatar | 1 | 3% |
| Unknown | 33 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 23% |
| Student > Ph. D. Student | 7 | 20% |
| Researcher | 5 | 14% |
| Student > Bachelor | 3 | 9% |
| Student > Doctoral Student | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 10 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 6 | 17% |
| Medicine and Dentistry | 4 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 9% |
| Engineering | 3 | 9% |
| Agricultural and Biological Sciences | 2 | 6% |
| Other | 6 | 17% |
| Unknown | 11 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2016.
All research outputs
#15,384,989
of 22,889,074 outputs
Outputs from Journal of Translational Medicine
#2,239
of 4,004 outputs
Outputs of similar age
#202,378
of 320,232 outputs
Outputs of similar age from Journal of Translational Medicine
#42
of 68 outputs
Altmetric has tracked 22,889,074 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,004 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,232 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.