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Parasite dynamics in the peripheral blood and the placenta during pregnancy-associated malaria infection

Overview of attention for article published in Malaria Journal, September 2016
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  • Above-average Attention Score compared to outputs of the same age (58th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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5 tweeters

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83 Mendeley
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Title
Parasite dynamics in the peripheral blood and the placenta during pregnancy-associated malaria infection
Published in
Malaria Journal, September 2016
DOI 10.1186/s12936-016-1541-x
Pubmed ID
Authors

Lauren M. Cohee, Linda Kalilani-Phiri, Patricia Mawindo, Sudhaunshu Joshi, Matthew Adams, Leo Kenefic, Christopher G. Jacob, Terrie E. Taylor, Miriam K. Laufer

Abstract

Malaria infections during pregnancy lead to sequestration of parasite infected red blood cells in the placenta. Placental infection can result in adverse outcomes for mothers and infants. Despite many studies, it remains unclear which peripheral blood infections during pregnancy lead to development of placental malaria. Understanding the timing of peripheral infections that lead to placental malaria and the ability of intermittent preventive treatment with sulfadoxine-pyrimethamine (SP-IPT) and artemisinin-based combination therapy to clear infections will enable the rational design of new interventions to decrease the burden of malaria in pregnancy. Microsatellite markers were used to genotype peripheral and placental malaria infections in an observational cohort in Blantyre, Malawi. Genotypes were compared to determine the timing of infections that sequester in the placenta. The effects of SP-IPT and artemether-lumefantrine as curative treatment were also evaluated by assessing the occurrence of peripheral infections or matching genotypes between peripheral and placental parasites following treatment. Genotypes from 92 peripheral samples prior to delivery, 26 peripheral samples at delivery, and 29 placental samples were compared. Thirty percent of women with genotyped parasites in their placentas that had peripheral infections detected during pregnancy had matching peripheral-placental genotypes. Matching genotypes were not associated with gestational age and occurred from 13 to 39 weeks. Among women with more than one genotyped peripheral infection during pregnancy, 80 % had persistent infection with the same genotype while the remaining were new infections. Among infections treated with SP or artemether-lumefantrine, 28/84 (33 %) and 9/56 (16 %) had infection detected after treatment, respectively. Recrudescent infections were detected after both treatments and occurred up to 76 days after treatment. Women treated with SP-IPT and artemether-lumefantrine had genotypes matching treated infections detected in the placenta. Placental malaria can occur at any time during pregnancy. In the context of late enrollment in antenatal care, interventions that protect all women of childbearing age and throughout pregnancy are needed. Currently used medications do not always clear peripheral or placental infections. The ability of anti-malarial drugs to prevent or clear placental infections should be considered in the development of future interventions.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 1%
Unknown 82 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 17%
Researcher 13 16%
Student > Ph. D. Student 11 13%
Student > Bachelor 10 12%
Student > Doctoral Student 6 7%
Other 16 19%
Unknown 13 16%
Readers by discipline Count As %
Medicine and Dentistry 25 30%
Agricultural and Biological Sciences 11 13%
Biochemistry, Genetics and Molecular Biology 9 11%
Immunology and Microbiology 6 7%
Nursing and Health Professions 3 4%
Other 10 12%
Unknown 19 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2016.
All research outputs
#3,626,310
of 8,425,604 outputs
Outputs from Malaria Journal
#1,549
of 2,962 outputs
Outputs of similar age
#104,079
of 253,826 outputs
Outputs of similar age from Malaria Journal
#57
of 111 outputs
Altmetric has tracked 8,425,604 research outputs across all sources so far. This one has received more attention than most of these and is in the 56th percentile.
So far Altmetric has tracked 2,962 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,826 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 111 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.