Title |
The restorative role of annexin A1 at the blood–brain barrier
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Published in |
Fluids and Barriers of the CNS, September 2016
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DOI | 10.1186/s12987-016-0043-0 |
Pubmed ID | |
Authors |
Simon McArthur, Rodrigo Azevedo Loiola, Elisa Maggioli, Mariella Errede, Daniela Virgintino, Egle Solito |
Abstract |
Annexin A1 is a potent anti-inflammatory molecule that has been extensively studied in the peripheral immune system, but has not as yet been exploited as a therapeutic target/agent. In the last decade, we have undertaken the study of this molecule in the central nervous system (CNS), focusing particularly on the primary interface between the peripheral body and CNS: the blood-brain barrier. In this review, we provide an overview of the role of this molecule in the brain, with a particular emphasis on its functions in the endothelium of the blood-brain barrier, and the protective actions the molecule may exert in neuroinflammatory, neurovascular and metabolic disease. We focus on the possible new therapeutic avenues opened up by an increased understanding of the role of annexin A1 in the CNS vasculature, and its potential for repairing blood-brain barrier damage in disease and aging. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 60 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 22% |
Student > Bachelor | 11 | 18% |
Student > Master | 8 | 13% |
Professor > Associate Professor | 3 | 5% |
Professor | 2 | 3% |
Other | 8 | 13% |
Unknown | 15 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 9 | 15% |
Agricultural and Biological Sciences | 9 | 15% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Medicine and Dentistry | 6 | 10% |
Immunology and Microbiology | 2 | 3% |
Other | 8 | 13% |
Unknown | 19 | 32% |