Title |
Identification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug development
|
---|---|
Published in |
Malaria Journal, February 2013
|
DOI | 10.1186/1475-2875-12-47 |
Pubmed ID | |
Authors |
Byoung Yul Soh, Hyun-Ok Song, Yoonji Lee, Junghyun Lee, Kusuma Kaewintajuk, Binna Lee, Yun-Young Choi, Jeong Hoon Cho, Sun Choi, Hyun Park |
Abstract |
With the increasing resistance of malaria parasites to available drugs, there is an urgent demand to develop new anti-malarial drugs. Calpain inhibitor, ALLN, is proposed to inhibit parasite proliferation by suppressing haemoglobin degradation. This provides Plasmodium calpain as a potential target for drug development. Pf-calpain, a cysteine protease of Plasmodium falciparum, belongs to calpain-7 family, which is an atypical calpain not harboring Ca2+-binding regulatory motifs. In this present study, in order to establish the screening system for Pf-calpain specific inhibitors, the active form of Pf-calpain was first identified. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 4% |
India | 2 | 4% |
Japan | 1 | 2% |
Canada | 1 | 2% |
Unknown | 45 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 22% |
Researcher | 10 | 20% |
Student > Bachelor | 6 | 12% |
Student > Master | 4 | 8% |
Other | 3 | 6% |
Other | 9 | 18% |
Unknown | 8 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 27% |
Computer Science | 6 | 12% |
Biochemistry, Genetics and Molecular Biology | 5 | 10% |
Chemistry | 4 | 8% |
Medicine and Dentistry | 4 | 8% |
Other | 6 | 12% |
Unknown | 12 | 24% |