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Identification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug development

Overview of attention for article published in Malaria Journal, February 2013
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Title
Identification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug development
Published in
Malaria Journal, February 2013
DOI 10.1186/1475-2875-12-47
Pubmed ID
Authors

Byoung Yul Soh, Hyun-Ok Song, Yoonji Lee, Junghyun Lee, Kusuma Kaewintajuk, Binna Lee, Yun-Young Choi, Jeong Hoon Cho, Sun Choi, Hyun Park

Abstract

With the increasing resistance of malaria parasites to available drugs, there is an urgent demand to develop new anti-malarial drugs. Calpain inhibitor, ALLN, is proposed to inhibit parasite proliferation by suppressing haemoglobin degradation. This provides Plasmodium calpain as a potential target for drug development. Pf-calpain, a cysteine protease of Plasmodium falciparum, belongs to calpain-7 family, which is an atypical calpain not harboring Ca2+-binding regulatory motifs. In this present study, in order to establish the screening system for Pf-calpain specific inhibitors, the active form of Pf-calpain was first identified.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 4%
India 2 4%
Japan 1 2%
Canada 1 2%
Unknown 45 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 22%
Researcher 10 20%
Student > Bachelor 6 12%
Student > Master 4 8%
Other 3 6%
Other 9 18%
Unknown 8 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 27%
Computer Science 6 12%
Biochemistry, Genetics and Molecular Biology 5 10%
Chemistry 4 8%
Medicine and Dentistry 4 8%
Other 6 12%
Unknown 12 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2013.
All research outputs
#15,262,171
of 22,694,633 outputs
Outputs from Malaria Journal
#4,455
of 5,542 outputs
Outputs of similar age
#182,538
of 283,057 outputs
Outputs of similar age from Malaria Journal
#64
of 89 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,542 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,057 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.