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Membrane-associated GRP78 helps subgroup J avian leucosis virus enter cells

Overview of attention for article published in Veterinary Research, January 2016
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1 tweeter

Citations

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10 Dimensions

Readers on

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7 Mendeley

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Title
Membrane-associated GRP78 helps subgroup J avian leucosis virus enter cells
Published in
Veterinary Research, January 2016
DOI 10.1186/s13567-016-0373-6
Pubmed ID
27599847
Authors

Lin Wang, Lin Wang, Mei Mei, Aijian Qin, Jianqiang Ye, Kun Qian, Hongxia Shao

Abstract

We previously identified chicken Annexin A2 (chANXA2) as a novel receptor for retrovirus avian leucosis virus subgroup J (ALV-J), using a DF1 cell line expressing the viral envelope (env) protein. To further probe whether other proteins participate in virus infection, we investigated several host proteins from co-immunoprecipitation with the DF1 cell line expressing viral env. Mass spectrometry analysis indicates that the chicken glucose-regulation protein 78 (chGRP78) of the DF1 membrane interacted with the ALV-J env protein. The results revealed that antibodies or siRNA to chGRP78 significantly inhibited ALV-J infection and replication, and over-expression of chGRP78 enabled the entry of ALV-J into non-susceptible cells. Taken together, these results are the first to report that chGRP78 functions to help ALV-J enter cells.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 29%
Unspecified 1 14%
Librarian 1 14%
Student > Doctoral Student 1 14%
Unknown 2 29%
Readers by discipline Count As %
Immunology and Microbiology 2 29%
Unspecified 1 14%
Agricultural and Biological Sciences 1 14%
Business, Management and Accounting 1 14%
Unknown 2 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2016.
All research outputs
#6,391,428
of 8,422,812 outputs
Outputs from Veterinary Research
#438
of 605 outputs
Outputs of similar age
#178,323
of 253,833 outputs
Outputs of similar age from Veterinary Research
#19
of 23 outputs
Altmetric has tracked 8,422,812 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 605 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,833 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

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