Title |
XENON in medical area: emphasis on neuroprotection in hypoxia and anesthesia
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Published in |
Medical Gas Research, February 2013
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DOI | 10.1186/2045-9912-3-4 |
Pubmed ID | |
Authors |
Ecem Esencan, Simge Yuksel, Yusuf Berk Tosun, Alexander Robinot, Ihsan Solaroglu, John H Zhang |
Abstract |
Xenon is a medical gas capable of establishing neuroprotection, inducing anesthesia as well as serving in modern laser technology and nuclear medicine as a contrast agent. In spite of its high cost, its lack of side effects, safe cardiovascular and organoprotective profile and effective neuroprotective role after hypoxic-ischemic injury (HI) favor its applications in clinics. Xenon performs its anesthetic and neuroprotective functions through binding to glycine site of glutamatergic N-methyl-D-aspartate (NMDA) receptor competitively and blocking it. This blockage inhibits the overstimulation of NMDA receptors, thus preventing their following downstream calcium accumulating cascades. Xenon is also used in combination therapies together with hypothermia or sevoflurane. The neuroprotective effects of xenon and hypothermia cooperate synergistically whether they are applied synchronously or asynchronously. Distinguishing properties of Xenon promise for innovations in medical gas field once further studies are fulfilled and Xenon's high cost is overcome. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 25% |
United States | 1 | 13% |
Mexico | 1 | 13% |
Spain | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 88% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 3% |
Belgium | 1 | 1% |
Unknown | 71 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 15 | 20% |
Student > Bachelor | 10 | 14% |
Researcher | 9 | 12% |
Student > Ph. D. Student | 9 | 12% |
Other | 6 | 8% |
Other | 9 | 12% |
Unknown | 16 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 23% |
Chemistry | 10 | 14% |
Agricultural and Biological Sciences | 6 | 8% |
Physics and Astronomy | 5 | 7% |
Engineering | 4 | 5% |
Other | 13 | 18% |
Unknown | 19 | 26% |