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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Multigenerational epigenetic effects of nicotine on lung function
|
|---|---|
| Published in |
BMC Medicine, February 2013
|
| DOI | 10.1186/1741-7015-11-27 |
| Pubmed ID | |
| Authors |
Frances M Leslie |
| Abstract |
A recent preclinical study has shown that not only maternal smoking but also grandmaternal smoking is associated with elevated pediatric asthma risk. Using a well-established rat model of in utero nicotine exposure, Rehan et al. have now demonstrated multigenerational effects of nicotine that could explain this 'grandmother effect'. F1 offspring of nicotine-treated pregnant rats exhibited asthma-like changes to lung function and associated epigenetic changes to DNA and histones in both lungs and gonads. These alterations were blocked by co-administration of the peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, implicating downregulation of this receptor in the nicotine effects. F2 offspring of F1 mated animals exhibited similar changes in lung function to that of their parents, even though they had never been exposed to nicotine. Thus epigenetic mechanisms appear to underlie the multigenerational transmission of a nicotine-induced asthma-like phenotype. These findings emphasize the need for more effective smoking cessation strategies during pregnancy, and cast further doubt on the safety of using nicotine replacement therapy to reduce tobacco use in pregnant women.Please see related article: http://www.biomedcentral.com/1741-7015/10/129. |
X Demographics
The data shown below were collected from the profiles of 29 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 14% |
| Argentina | 3 | 10% |
| Australia | 2 | 7% |
| United Kingdom | 2 | 7% |
| Canada | 1 | 3% |
| Netherlands | 1 | 3% |
| Russia | 1 | 3% |
| Mexico | 1 | 3% |
| Spain | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 13 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 69% |
| Practitioners (doctors, other healthcare professionals) | 4 | 14% |
| Scientists | 4 | 14% |
| Unknown | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 1% |
| Portugal | 1 | 1% |
| Romania | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 82 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 15% |
| Researcher | 12 | 14% |
| Student > Bachelor | 12 | 14% |
| Student > Master | 9 | 10% |
| Other | 5 | 6% |
| Other | 15 | 17% |
| Unknown | 20 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 20% |
| Agricultural and Biological Sciences | 16 | 19% |
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Social Sciences | 5 | 6% |
| Nursing and Health Professions | 3 | 3% |
| Other | 13 | 15% |
| Unknown | 21 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2015.
All research outputs
#1,113,079
of 25,654,806 outputs
Outputs from BMC Medicine
#781
of 4,067 outputs
Outputs of similar age
#9,456
of 292,924 outputs
Outputs of similar age from BMC Medicine
#22
of 81 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,067 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.9. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,924 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.