Title |
EphB2 signaling regulates lesion-induced axon sprouting but not critical period length in the postnatal auditory brainstem
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Published in |
Neural Development, February 2013
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DOI | 10.1186/1749-8104-8-2 |
Pubmed ID | |
Authors |
Paul A Nakamura, Karina S Cramer |
Abstract |
Studies of developmental plasticity may provide insight into plasticity during adulthood, when neural circuitry is less responsive to losses or changes in input. In the mammalian auditory brainstem, globular bushy cell axons of the ventral cochlear nucleus (VCN) innervate the contralateral medial nucleus of the trapezoid body (MNTB) principal neurons. VCN axonal terminations in MNTB, known as calyces of Held, are very large and specialized for high-fidelity transmission of auditory information. Following unilateral deafferentation during postnatal development, VCN axons from the intact side form connections with novel targets, including the ipsilateral MNTB. EphB signaling has been shown to play a role in this process during the first postnatal week, but mechanisms involved in this reorganization during later developmental periods remain unknown. |
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