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Neoadjuvant chemoradiation therapy for borderline pancreatic adenocarcinoma: report of two cases

Overview of attention for article published in World Journal of Surgical Oncology, February 2013
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Title
Neoadjuvant chemoradiation therapy for borderline pancreatic adenocarcinoma: report of two cases
Published in
World Journal of Surgical Oncology, February 2013
DOI 10.1186/1477-7819-11-37
Pubmed ID
Authors

José Galindo, Mauricio Gabrielli, Juan Francisco Guerra, Juan Carlos Cassina, Marcelo Garrido, Nicolás Jarufe, Yerko Borghero, Jorge Madrid, Pablo Zoroquiain, Juan Carlos Roa, Jorge Martínez

Abstract

Pancreatic cancer remains as one of the most aggressive human neoplasms, with overall poor survival rates. Radical surgery of the primary lesion is the best option for treatment. Borderline resectable pancreatic tumors (BRPT), defined as partial involvement of peripancreatic vasculature, may benefit from neoadjuvant therapy. We report on the first two BRPT cases treated with neoadjuvant chemoradiation at our institution. Preoperative CT and MRI demonstrated pancreatic tumors encasing the porto-mesenteric confluence suggestive of BRPT. Patients received neoadjuvant chemotherapy (gemcitabine/cisplatin), followed by radiochemotherapy. After treatment, follow-up images demonstrated tumor downsize, allowing for the tumors to be considered then as resectable. They underwent partial pancreatoduodenectomies (Whipple procedure). In case 1, histopathology revealed a complete, margin-free resection, whereas in case 2 there was a complete pathological response, with no evidence of residual tumor. According to the literature, our initial experience using neoadjuvant chemoradiotherapy on BRPT allowed us to downsize the tumor and, subsequently, to perform a curative surgery.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Other 3 12%
Student > Bachelor 3 12%
Student > Doctoral Student 3 12%
Student > Master 2 8%
Librarian 1 4%
Other 4 15%
Unknown 10 38%
Readers by discipline Count As %
Medicine and Dentistry 9 35%
Agricultural and Biological Sciences 3 12%
Social Sciences 1 4%
Unknown 13 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2013.
All research outputs
#18,327,422
of 22,694,633 outputs
Outputs from World Journal of Surgical Oncology
#1,019
of 2,039 outputs
Outputs of similar age
#219,339
of 282,906 outputs
Outputs of similar age from World Journal of Surgical Oncology
#38
of 83 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,039 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
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We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.