Title |
Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling
|
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Published in |
BMC Bioinformatics, February 2013
|
DOI | 10.1186/1471-2105-14-41 |
Pubmed ID | |
Authors |
Yun-feng Qi, Yan-xin Huang, Hong-yan Wang, Yu Zhang, Yong-li Bao, Lu-guo Sun, Yin Wu, Chun-lei Yu, Zhen-bo Song, Li-hua Zheng, Ying Sun, Guan-nan Wang, Yu-xin Li |
Abstract |
Interferon-gamma (IFN-gamma) and interleukin-6 (IL-6) are multifunctional cytokines that regulate immune responses, cell proliferation, and tumour development and progression, which frequently have functionally opposing roles. The cellular responses to both cytokines are activated via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. During the past 10 years, the crosstalk mechanism between the IFN-gamma and IL-6 pathways has been studied widely and several biological hypotheses have been proposed, but the kinetics and detailed crosstalk mechanism remain unclear. |
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Norway | 1 | 100% |
Demographic breakdown
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Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 61 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 23% |
Student > Ph. D. Student | 11 | 18% |
Student > Bachelor | 9 | 15% |
Student > Postgraduate | 6 | 10% |
Student > Doctoral Student | 4 | 7% |
Other | 13 | 21% |
Unknown | 4 | 7% |
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Mathematics | 5 | 8% |
Immunology and Microbiology | 5 | 8% |
Medicine and Dentistry | 4 | 7% |
Other | 8 | 13% |
Unknown | 6 | 10% |