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Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus

Overview of attention for article published in Alzheimer's Research & Therapy, September 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)

Mentioned by

news
1 news outlet

Citations

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38 Dimensions

Readers on

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54 Mendeley
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Title
Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus
Published in
Alzheimer's Research & Therapy, September 2016
DOI 10.1186/s13195-016-0206-x
Pubmed ID
Authors

Shuman Zhang, Pan Wang, Lili Ren, Chunli Hu, Jing Bi

Abstract

Amyloid-beta (Aβ) plays a key role in Alzheimer's disease (AD) pathogenesis, and soluble Aβ oligomers are more cytotoxic than Aβ fibrils. Recent evidence suggests that Notch signaling is affected by AD and other brain diseases. Melatonin exerts beneficial effects on many aspects of AD and may protect against myocardial ischemia via Notch1 signaling regulation. Therefore, we hypothesized that the Notch1 signaling pathway is involved in the neuroprotective role of melatonin against soluble Aβ1-42. An AD rat model was established via repeated intracerebroventricular administration of soluble Aβ1-42. Melatonin treatment was administered 24 hours prior to Aβ1-42 administration via an intraperitoneal injection. The effects of melatonin on spatial learning and memory, synaptic plasticity, and astrogliosis were investigated. The expression of several Notch1 signaling components, including Notch1, the Notch1 intracellular domain (NICD), Hairy and enhancer of split 1 (Hes1, a downstream effector of Notch), and Musashi1 (a positive regulator of Notch), were examined using immunohistochemistry, western blotting, and quantitative real-time PCR. In vitro studies were conducted to determine whether the melatonin-mediated protection against Aβ1-42 was inhibited by DAPT, an inhibitor of Notch signaling. Melatonin improved the Aβ1-42-induced impairment in spatial learning and memory, attenuated synaptic dysfunction, and reduced astrogliosis. Melatonin also ameliorated the effects of Aβ1-42 on Notch1, NICD, Hes1, and Musashi1. The in vitro studies demonstrated that DAPT effectively blocked the neuroprotective effect of melatonin against Aβ1-42. These findings suggest that melatonin may improve the soluble Aβ1-42-induced impairment of spatial learning and memory, synaptic plasticity, and astrogliosis via the Musashi1/Notch1/Hes1 signaling pathway.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 53 98%

Demographic breakdown

Readers by professional status Count As %
Other 8 15%
Student > Ph. D. Student 8 15%
Student > Bachelor 7 13%
Student > Master 6 11%
Student > Doctoral Student 3 6%
Other 5 9%
Unknown 17 31%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 11%
Neuroscience 5 9%
Medicine and Dentistry 5 9%
Biochemistry, Genetics and Molecular Biology 5 9%
Chemistry 3 6%
Other 9 17%
Unknown 21 39%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2016.
All research outputs
#1,235,711
of 8,422,812 outputs
Outputs from Alzheimer's Research & Therapy
#188
of 374 outputs
Outputs of similar age
#54,820
of 252,820 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#11
of 14 outputs
Altmetric has tracked 8,422,812 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 374 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,820 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.