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RabGDI controls axonal midline crossing by regulating Robo1 surface expression

Overview of attention for article published in Neural Development, November 2012
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  • High Attention Score compared to outputs of the same age and source (80th percentile)

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Citations

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Title
RabGDI controls axonal midline crossing by regulating Robo1 surface expression
Published in
Neural Development, November 2012
DOI 10.1186/1749-8104-7-36
Pubmed ID
Authors

Melanie Philipp, Vera Niederkofler, Marc Debrunner, Tobias Alther, Beat Kunz, Esther T Stoeckli

Abstract

Axons navigate to their future synaptic targets with the help of choice points, intermediate targets that express axon guidance cues. Once they reach a choice point, axons need to switch their response from attraction to repulsion in order to move on with the next stage of their journey. The mechanisms underlying the change in axonal responsiveness are poorly understood. Commissural axons become sensitive to the repulsive activity of Slits when they cross the ventral midline of the CNS. Responsiveness to Slits depends on surface expression of Robo receptors. In Drosophila, Commissureless (Comm) plays a crucial regulatory role in midline crossing by keeping Robo levels low on precommissural axons. Interestingly, to date no vertebrate homolog of comm has been identified. Robo3/Rig1 has been shown to control Slit sensitivity before the midline, but without affecting Robo1 surface expression.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 80 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 23 28%
Student > Ph. D. Student 16 20%
Researcher 13 16%
Student > Postgraduate 5 6%
Student > Bachelor 3 4%
Other 13 16%
Unknown 8 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 33%
Neuroscience 17 21%
Biochemistry, Genetics and Molecular Biology 15 19%
Medicine and Dentistry 3 4%
Social Sciences 2 2%
Other 7 9%
Unknown 10 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2013.
All research outputs
#15,262,171
of 22,694,633 outputs
Outputs from Neural Development
#135
of 226 outputs
Outputs of similar age
#114,590
of 182,178 outputs
Outputs of similar age from Neural Development
#1
of 5 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 226 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 182,178 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them