Title |
RabGDI controls axonal midline crossing by regulating Robo1 surface expression
|
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Published in |
Neural Development, November 2012
|
DOI | 10.1186/1749-8104-7-36 |
Pubmed ID | |
Authors |
Melanie Philipp, Vera Niederkofler, Marc Debrunner, Tobias Alther, Beat Kunz, Esther T Stoeckli |
Abstract |
Axons navigate to their future synaptic targets with the help of choice points, intermediate targets that express axon guidance cues. Once they reach a choice point, axons need to switch their response from attraction to repulsion in order to move on with the next stage of their journey. The mechanisms underlying the change in axonal responsiveness are poorly understood. Commissural axons become sensitive to the repulsive activity of Slits when they cross the ventral midline of the CNS. Responsiveness to Slits depends on surface expression of Robo receptors. In Drosophila, Commissureless (Comm) plays a crucial regulatory role in midline crossing by keeping Robo levels low on precommissural axons. Interestingly, to date no vertebrate homolog of comm has been identified. Robo3/Rig1 has been shown to control Slit sensitivity before the midline, but without affecting Robo1 surface expression. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 80 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 23 | 28% |
Student > Ph. D. Student | 16 | 20% |
Researcher | 13 | 16% |
Student > Postgraduate | 5 | 6% |
Student > Bachelor | 3 | 4% |
Other | 13 | 16% |
Unknown | 8 | 10% |
Readers by discipline | Count | As % |
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Social Sciences | 2 | 2% |
Other | 7 | 9% |
Unknown | 10 | 12% |