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GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia

Overview of attention for article published in Biology Direct, February 2013
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Title
GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia
Published in
Biology Direct, February 2013
DOI 10.1186/1745-6150-8-5
Pubmed ID
Authors

Hedi Hegyi

Abstract

Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease: by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 3%
Canada 1 3%
Unknown 32 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 21%
Student > Ph. D. Student 7 21%
Researcher 5 15%
Student > Doctoral Student 3 9%
Student > Bachelor 3 9%
Other 3 9%
Unknown 6 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 35%
Biochemistry, Genetics and Molecular Biology 5 15%
Medicine and Dentistry 5 15%
Neuroscience 2 6%
Computer Science 1 3%
Other 3 9%
Unknown 6 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2015.
All research outputs
#14,161,257
of 22,694,633 outputs
Outputs from Biology Direct
#338
of 487 outputs
Outputs of similar age
#168,017
of 282,966 outputs
Outputs of similar age from Biology Direct
#8
of 8 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 487 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,966 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one.