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Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies

Overview of attention for article published in Fluids and Barriers of the CNS, February 2013
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Title
Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies
Published in
Fluids and Barriers of the CNS, February 2013
DOI 10.1186/2045-8118-10-11
Pubmed ID
Authors

Mélanie Morin-Brureau, Frédéric De Bock, Mireille Lerner-Natoli

Abstract

It is now recognized that the neuro-vascular unit (NVU) plays a key role in several neurological diseases including epilepsy, stroke, Alzheimer's disease, multiple sclerosis and the development of gliomas. Most of these disorders are associated with NVU dysfunction, due to overexpression of inflammatory factors such as vascular endothelial growth factor (VEGF). Various in vitro models have been developed previously to study the micro-environment of the blood-brain barrier (BBB). However none of these in vitro models contained a complete complement of NVU cells, nor maintained their interactions, thus minimizing the influence of the surrounding tissue on the BBB development and function. The organotypic hippocampal culture (OHC) is an integrative in vitro model that allows repeated manipulations over time to further understand the development of cell circuits or the mechanisms of brain diseases.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Romania 1 1%
Unknown 67 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 19%
Researcher 12 17%
Student > Master 8 12%
Student > Doctoral Student 7 10%
Student > Bachelor 5 7%
Other 15 22%
Unknown 9 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 26%
Neuroscience 16 23%
Medicine and Dentistry 8 12%
Biochemistry, Genetics and Molecular Biology 7 10%
Engineering 5 7%
Other 2 3%
Unknown 13 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2013.
All research outputs
#20,182,546
of 22,696,971 outputs
Outputs from Fluids and Barriers of the CNS
#313
of 356 outputs
Outputs of similar age
#249,693
of 282,966 outputs
Outputs of similar age from Fluids and Barriers of the CNS
#13
of 13 outputs
Altmetric has tracked 22,696,971 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 356 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,966 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.