Title |
Dynamic strain scanning optimization: an efficient strain design strategy for balanced yield, titer, and productivity. DySScO strategy for strain design
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Published in |
BMC Biotechnology, February 2013
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DOI | 10.1186/1472-6750-13-8 |
Pubmed ID | |
Authors |
Kai Zhuang, Laurence Yang, William R Cluett, Radhakrishnan Mahadevan |
Abstract |
In recent years, constraint-based metabolic models have emerged as an important tool for metabolic engineering; a number of computational algorithms have been developed for identifying metabolic engineering strategies where the production of the desired chemical is coupled with the growth of the organism. A caveat of the existing algorithms is that they do not take the bioprocess into consideration; as a result, while the product yield can be optimized using these algorithms, the product titer and productivity cannot be optimized. In order to address this issue, we developed the Dynamic Strain Scanning Optimization (DySScO) strategy, which integrates the Dynamic Flux Balance Analysis (dFBA) method with existing strain algorithms. |
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Denmark | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 2 | 1% |
Denmark | 2 | 1% |
United Kingdom | 1 | <1% |
Brazil | 1 | <1% |
Sweden | 1 | <1% |
United States | 1 | <1% |
Unknown | 138 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 38 | 26% |
Researcher | 27 | 18% |
Student > Master | 24 | 16% |
Student > Bachelor | 12 | 8% |
Student > Doctoral Student | 8 | 5% |
Other | 20 | 14% |
Unknown | 17 | 12% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 31 | 21% |
Engineering | 30 | 21% |
Chemical Engineering | 10 | 7% |
Computer Science | 7 | 5% |
Other | 8 | 5% |
Unknown | 22 | 15% |