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A robust and efficient statistical method for genetic association studies using case and control samples from multiple cohorts

Overview of attention for article published in BMC Genomics, February 2013
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Title
A robust and efficient statistical method for genetic association studies using case and control samples from multiple cohorts
Published in
BMC Genomics, February 2013
DOI 10.1186/1471-2164-14-88
Pubmed ID
Authors

Minghui Wang, Lin Wang, Ning Jiang, Tianye Jia, Zewei Luo

Abstract

The theoretical basis of genome-wide association studies (GWAS) is statistical inference of linkage disequilibrium (LD) between any polymorphic marker and a putative disease locus. Most methods widely implemented for such analyses are vulnerable to several key demographic factors and deliver a poor statistical power for detecting genuine associations and also a high false positive rate. Here, we present a likelihood-based statistical approach that accounts properly for non-random nature of case-control samples in regard of genotypic distribution at the loci in populations under study and confers flexibility to test for genetic association in presence of different confounding factors such as population structure, non-randomness of samples etc.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
United States 1 4%
Germany 1 4%
Unknown 24 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 33%
Researcher 7 26%
Student > Doctoral Student 2 7%
Student > Master 2 7%
Lecturer > Senior Lecturer 1 4%
Other 2 7%
Unknown 4 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 41%
Biochemistry, Genetics and Molecular Biology 4 15%
Medicine and Dentistry 2 7%
Psychology 2 7%
Arts and Humanities 1 4%
Other 2 7%
Unknown 5 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2013.
All research outputs
#21,264,673
of 23,881,329 outputs
Outputs from BMC Genomics
#9,455
of 10,793 outputs
Outputs of similar age
#256,669
of 289,623 outputs
Outputs of similar age from BMC Genomics
#318
of 357 outputs
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